Protein kinase C alteration is an early biochemical marker in Alzheimer's disease

Protein kinase C alteration is an early biochemical marker in Alzheimer's disease.

Neuritic (senile) plaques are a hallmark of the pathology found in the brain of patients afflicted with Alzheimer's disease (AD). Neuritic plaques have been considered to be composed of an amyloid core surrounded by dilated neurites, although the use of anti-beta/A4-protein antibody revealed the presence of diffuse plaques without a nuclear-like central mass or surrounding paired helical filame...

Protein Kinase Cε in the Platelet and Hippocampal Tissue as a Diagnostic Biological Marker in Alzheimer Disease

Introduction: Alzheimer disease (AD) is a neurodegenerative disorder characterized by the progressive loss of memory and other cognitive functions. Protein kinase Cε (PKCε) is an isoform that most effectively suppresses amyloid beta (Aβ) production and synaptic loss. Methods: In this study, spatial learning and memory for treated rats were evaluated by the Morris water maze test. The activity ...

Evaluation of C-reactive protein as a biochemical marker for assessing disease severity in Malaria

Levels of C-reactive protein , a well characterised serum acute phase protein were measured in a total of 32 patients admitted to JK hospital with the diagnosis of Malaria (18 vivax malaria and 14 falciparum malaria) . Serum C-reactive protein concentrations were measured daily in all the patients over a seven day period .Percentage parasitemia , platelet count , serum bilirubin , alanine amino...

Is microalbuminuria an early marker of diabetic renal disease?

Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis.

Protein kinase C (PKC) has been implicated in colon carcinogenesis in humans and in rodent models. However, little is known about the specific role of individual PKC isozymes in this process. We recently demonstrated that elevated expression of PKC betaII in the colonic epithelium induces hyperproliferation in vivo (N. R. Murray et al., J. Cell Biol., 145: 699-711, 1999). Because hyperprolifera...